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Flask is a micro framework framework written in Python that can be used to build APIs, web services and web applications. Flask is designed from the bottom up to be extremely minimal and easy to use, where your whole application can fit into one single Python file. The framework includes no database abstraction layer, form validation, or any other components, by design. However pre-existing third-party libraries provide common functionality needed to build production ready applications and services.

CherryPy is a free and open-source object-oriented HTTP and web framework written in Python. CherryPy allows developer to build web application the same way they would build any other object-oriented program. The design of CherryPy result in a simpler and faster development experience with more readable code. CherryPy is distributed under a BSD license and loved by many Python web developers.

Web2py is a free and open-source web application framework written Python. With Web2py, developers can build dynamic applications with ease. The framework ships with "batteries included" for fast multi-threaded web server, SQL database and web-based interface. Web2py also ships with a web-based IDE that can be used to manage your application using your browser. A single instance can also run multiple web applications using different databases. Web2py free of charge under the LGPLv3 License.

Django is a high-level Python web development framework used for building web application at scale with speed. The framework adhere to a clean and pragmatic design that lets developers develop rapidly. Django ships as a "batteries included" framework and contains many of the features needed for most web applications such as an admin panel, an ORM and templating language. It takes much of the hassle out of web development and lets developers focus on writing their application instead of focusing on authentication, authorization and security.

Ruby on Rails is an iconic, free and open source, server-side web application framework released under the liberal MIT license. The Ruby-based framework has helped millions of developer make their ideas a reality. The framework is opinionated and promotes best standards and practices for web development. When combining that with a community that is open, helpful and guiding, it's not hard to see why Ruby on Rails is one of the most loved web application frameworks to this day. Ruby on Rails is also used by industry giants like Basecamp, HEY, GitHub, Shopify, Airbnb, Twitch, SoundCloud, Hulu, Zendesk, Square, Cookpad.