Software
β-agonists Hapten
Aided by our rich experience and professional scientists, Creative Biolabs has completed a series of challenges in the past years. In particular, we have established an advanced β-agonist hapten design and synthesis platform which enables us to offer a series of high-quality services for our worldwide customers.
β-agonists Hapten Design and Synthesis
The significant role of β-agonist haptens in the development of small-molecule antibodies has aroused much attention in the past few years. Moreover, different types of β-agonist haptens, such as class-specific and compound-specific β-agonist haptens, have been generated for enhancing the efficacy of therapeutic antibodies in the clinic. Following this trend, Creative Biolabs provides state-of-art hapten-based services for a wide range of β-agonist design and synthesis.
Steroid Hormones Hapten
By judicious attachment of steroid hormone haptens to a protein carrier, it tactfully solves the problem of non-immunogenic or low-immunogenic of low-molecular-weight hapten compounds, successfully eliciting the formation of anti-hapten antibodies. These antibodies direct against steroid hormone haptens and are important both for assays of hormones and drugs in biological fluids or for therapeutic applications in tumor therapy. Based on the advance of chemical criteria, theoretical studies, and molecular modeling assisted hapten design, Creative Biolabs provides best-fit customized services for the design, modification, and synthesis of steroid hormone haptens and associated antibodies to meet customers’ demands.
Heavy Metals Hapten
The design, modification, and synthesis of metal-chelate hapten are the first steps to produce antibodies with bound heavy metals hapten that have many potential uses in medicine. As a leading provider in the field of hapten design, Creative Biolabs can accomplish customers' challenging projects for the best-fit design and synthesis of heavy metals hapten.
Metabolic Immune Checkpoint
Immunometabolism, the intricate interplay between metabolic processes and the immune system, has emerged as an exciting research domain over the last decade. As immunotherapy becomes a significant therapeutic strategy in the oncology landscape, understanding the metabolic immune checkpoints could pave the way for more effective treatments. Among several targets of interest, Interleukin-4 Induced Gene 1 (IL4I1) holds considerable promise. Creative Biolabs delves into the function, mechanism, and therapeutic potential of IL4I1 in battling diseases such as cancer.
Trans-endocytosis of CTLA-4
Trans-endocytosis of CTLA-4 The minimal expression of CTLA-4 on the surface of T cells is due to its own highly endocytotic properties, which allow it to continuously circulate at the cell membrane and inside the cell. In addition to competing with CD28 for the binding of CD80/CD86 molecules, CTLA-4 swallows both molecules into the cell interior, resulting in a reduction of CD80/CD86 on the surface of APCs.
Immune Checkpoint Drug Design
The research-based pharmaceutical industry has increasingly employed modern medicinal chemistry methods, including molecular modeling. This field has progressed together with advances in biomolecular spectroscopic techniques such as X-ray crystallography and nuclear magnetic resonance (NMR), which have enabled striking progress in molecular and structural biology. Based on our deep understanding of these advanced drug design strategies, Creative Biolabs has extensive experience in offering custom services for successful immune checkpoint drug design to meet our clients' demands precisely.
New Structure of LAG-3
New Structure of LAG-3 Researchers co-crystallized the LAG-3 D1-D4 domains with a single-chain variable fragment (scFv) of an F7 antagonist to characterize the structure of the LAG-3 extracellular domain. It was found that LAG-3 is formed as a homodimer through the D2 structural domain, with the remaining structural domains forming an elongated and curved arrangement. the dimer interface in D2 is at an angle, so that the D1 structural domain deviates from the central axis of the dimer and forms a V-shaped aperture. The dimerization interfaces in human and mouse LAG-3 structures share a broadly conserved set of residues, but the angles of D1D2 dimer formation are extremely different. This may result in different relative positions of the MHCII and FGL1 binding sites. This conformational difference between human and mouse LAG-3 may reflect two distinct functional states of LAG-3. In addition to resolving structural information on the extracellular structural domain of LAG-3, key interfacial residues in the LAG-3 D1 loop 2 were identified and it was demonstrated that LAG-3 binds MHCII and FGL1 via different molecular surfaces.
Pro-niosomes
Pro-vesicular approach has been proposed to enhance the stability of vesicles. Pro-niosomes is a compact semi-solid liquid crystalline product of non-ionic surfactant easily formed on dissolving the surfactant in minimal amount of acceptable solvent and the least amount of aqueous phase. As the first-in-class biotech developer and provider, scientists of Creative Biolabs focus on applying outstanding technologies to the discovery and development of potential drug delivery approaches, such as custom lipid-based drug delivery (LDD) services. Based on advanced technology and years of research, we are confident to provide high-quality custom services and products which can greatly assist your drug delivery project.
Polysaccharide coated liposome development
Polysaccharide coated liposomes are considered to be a physically and chemically stable system that can resist biochemical and physicochemical stresses in biological fluids. Some characteristics of them make their application in drug delivery rationalized: When plasma/serum or its components are present, the permeability of water-soluble encapsulated materials is reduced; Improve the stability against enzymatic attack and protect phospholipids from lipase and lipoxygenase; Mechanical and biochemical stability of biological stimuli, such as pH, osmotic pressure, ionic strength, temperature and dynamic challenges of biological fluids.