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NestJS is a free and open source JavaScript framework for building scalable Node.js web applications. The framework uses modern JavaScript and is built with TypeScript. NestJS is utilizing a multi paradigm model including Object Oriented Programming, Functional Programming and Functional Reactive Programming.

Sails.js is a JavaScript framework that makes it easy to build custom, enterprise-grade Node.js apps. It is designed to resemble the MVC architecture from frameworks like Ruby on Rails, but with support for the more modern, data-oriented style of web app development. The framework is suited for building applications with realtime features.

Django is a high-level Python web development framework used for building web application at scale with speed. The framework adhere to a clean and pragmatic design that lets developers develop rapidly. Django ships as a "batteries included" framework and contains many of the features needed for most web applications such as an admin panel, an ORM and templating language. It takes much of the hassle out of web development and lets developers focus on writing their application instead of focusing on authentication, authorization and security.

AdonisJS is a Node.js web framework designed for building micro-services with JavaScript and Typescript. The framework provides an elegant syntax and and the tools that gives developers the confidence to build structured projects at scale. AdonisJS also includes its own ORM called Lucid, which is an implementation of Active Record, written in JavaScript. The framework will make anyone coming from Laravel or Ruby on Rails to feel right at home in the JavaScript eco-system.

Build powerful, scalable applications, with minimal overhead and full out-of-the-box functionality with Hapi. It's a free and open-source JavaScript framework for Node.js that is developed for enterprise-grade applications. Companies like Walmart, Brave and Condé Nast build web-services with Hapi and rely on it at scale.

Express.js is a free and open-source web application framework for Node.js, released as free and open-source software under the MIT License. Express is designed for building fast web applications and APIs. In the Node.js community the Express framework is seen as the defacto standard when it comes to building such applications. The philosophy of the framework is to provide a small and robust toolset for building HTTP servers with JavaScript and Node.js. Express does not force you to use any specific database, ORM or templating language, as it leaves that up to you as a developer, to maximize freedom and choice. Express.js is used by companies and hobby developers alike to build single page JavaScript applications, websites, hybrids and public HTTP APIs.