Open Source Software
Online Booking System
Trawex is expert in designing online booking system specifically for tour, activity, vacation, sightseeing, and adventure businesses. We provide tourism businesses with the ability to take online bookings, process payments, and manage customers. We centralized travel website development company that provides scalable B2C & B2B solutions to regional travel operators & hospitality companies. For more details, Pls visit our website: https://www.trawex.com/online-booking-system.php
CMS Development Services
As the best CMS website development company, FlightsLogic offers services for all CMS platforms, CMS development worldwide. We offer CMS development services for all levels of businesses ranging from SMEs to large enterprises. Many business brands are aiming to build their own website on CMS to take complete control of their websites, now it’s your turn.
FlexClip
FlexClip is an onlineAI video creation platform that allows users to easily create and edit videos for various purposes such as marketing, social media, personal projects, education, and more. It provides a user-friendly interface with a range of tools and templates to streamline the video editing process. FlexClip offers features like drag-and-drop functionality, customizable templates, stock media libraries (including videos, photos, and music), text animations, transitions, and basic editing tools such as trimming, splitting, and merging clips.
Rentysa - Rental Script
Appysa Technologies provides best rental script with mobile app. We developed our rental marketplace script with flutter, laravel, mongoDb. Rentysa, an exceptional rental classified script that offers an exclusive renting experience. Users can easily register, browse, and book items for rent. With its immaculate features, Rentysa – a rental script, delivers a superior online rental classified platform. The sharing economy is booming, transforming how we access everything from cozy cabins to luxury yachts. Imagine empowering travelers with unique spaces or connecting car owners with potential renters – the possibilities are endless! But before setting sail (pun intended) on your online rental empire, choosing the right rental script is essential.This guide equips you with the knowledge to navigate the exciting world of online rental businesses. We'll explore popular niches, delve into script options, and empower you to pick the perfect platform to match your aspirations.Rental Niches: Where the Money FlowsThe online rental landscape offers a diverse range of opportunities.
India Tourism
Discover a comprehensive travel guide to India. Explore must-visit tourist destinations and uncover exciting activities to do across the country. Dive into travel stories and customize your trip with our trusted travel partners.
Web Application Development Services
FlightsLogic is a global web app development company that is purely engaged in developing high-performance, secure, and custom web applications using innovative technology. We provide the best Web Application Development Services to travel agencies, tour operators, and various businesses all over the globe.
P-dd.mobi Memory Card Data Recovery
Available Memory Card Data Recovery Software at www.p-dd.mobi helps to retrieves deleted files from formatted or re-formatted secure digital memory card.www.p-dd.mobi provides complete solution to regains your lost or deleted images, pictures, video, audio songs and other precious saved files from digital media storage device with advance disk scanning techniques using Memory Card Data Recovery Software.
XML Hotel Booking Engine
FlightsLogic, is the leading and innovative travel technology, and travel software development company worldwide. FlightsLogic XML Hotel Booking Engine is designed to automate processes and reduce the time and effort required to research and complete a hotel booking.
ADCC/CDC Enhancement in Therapeutic Antibody Development
Therapeutic antibodies, engineered through biotechnology, represent a specialized class of antibodies used in disease treatment. These antibodies are designed to target specific disease markers, such as malignant tumors, autoimmune disorders, and infectious diseases. Compared to traditional antibody therapies, therapeutic antibodies offer higher specificity and fewer side effects. In the realm of immunotherapy, antibody-dependent cell-mediated cytotoxicity (ADCC) stands out as a highly effective anti-tumor mechanism. ADCC enhancement refers to the bolstering of immune cells' ability to attack malignant cells, thereby enhancing the efficacy of immunotherapy. ADCC enhancement technology finds significant applications in the field of therapeutic antibodies, encompassing techniques like fucosylation engineering, Fc protein-engineering, cross-isotype engineering, and glyco- and Fc protein dual engineering. Furthermore, antibody-dependent cell phagocytosis (ADCP) plays a pivotal role in the action of therapeutic antibodies. The ADCP assay serves as an experimental method for studying antibody-dependent cell phagocytosis. This research investigates whether antibodies assist immune cells, such as macrophages, in recognizing, engulfing, and digesting labeled target cells or pathogens. Through the ADCP assay, researchers can assess whether therapeutic antibodies activate immune cells to attack and eliminate tumor cells, instilling renewed optimism in cancer treatment. CDC enhancement, a classical approach to fortifying the immune system, amplifies the cytotoxicity of antibodies. Immunotherapy often hinges on antibody action, and CDC enhancement accentuates the activation of the complement system by antibodies, inducing cell toxicity and ultimately eradicating target cells. In CDC enhancement, antibodies (typically therapeutic monoclonal antibodies) bind to antigens on the surface of target cells, triggering the activation of the C1q molecule in the complement system. C1q further instigates the complement cascade reaction in the immune system, culminating in the formation of the membrane attack complex (MAC). This process ruptures target cell membranes and leads to cell lysis, achieving cytotoxic effects on the target cells. Researchers assess the binding capacity of therapeutic antibodies with C1q through the C1q binding assay, determining the antibody's effectiveness in the immune response. Researchers have surmounted numerous challenges in disease treatment through advanced techniques such as the C1q binding Assay and ADCP assay. In cancer treatment, scientists have successfully developed a series of antibodies targeting specific antigens. These drugs activate immune cells, propelling them to engulf and annihilate cancer cells. The successful application of this immunotherapy brings renewed hope to tumor treatment. In the domain of autoimmune disease treatment, researchers are leveraging antibodies to target diseases resulting from immune system overactivation. Through meticulous C1q binding assay studies, scientists can pinpoint the most suitable antibodies for treatment, precisely modulating the immune system's activity to achieve therapeutic goals. Moreover, in the realm of treating viral and bacterial infections, the utilization of the ADCP assay is on the rise. Researchers have formulated a series of antibodies targeting pathogens, effectively eliminating infection sources by stimulating immune cells to engulf these pathogens. Consequently, this approach has significantly heightened the success rate of infectious disease treatments. With the continuous evolution of single-cell technologies and CRISPR gene editing techniques, researchers can delve deeper into cell death mechanisms, antibody structures, and immune cell functions. This progress will further accelerate research on ADCC enhancement, offering more precise and efficient means for disease treatment.
Cell Therapy: Surface Modification Technology Based on Cell Membrane
The cell membrane acts not only as a physical barrier but also as a functional organelle that regulates communication between cells and their environment. Functionalizing the cell membrane using synthetic molecules or nanostructures has the potential to enhance cellular functions beyond those achieved through natural evolution. Cell therapy represents a groundbreaking approach in treating major challenging diseases, including tissue injuries, degenerative diseases, and congenital metabolic disorders. The primary focus of biomedical research has always been on regulating cellular functions to maximize the efficiency of cell therapy. Given that the cell surface plays a critical role in cellular physiology and pathology by controlling recognition and communication between cells and their environment, functionalizing the cell surface emerges as an effective method for regulating cellular functions. We have developed a range of cell surface modification techniques based on molecular self-assembly approaches, wherein exogenous biomolecules and biomaterials are constructed on the cell surface through molecular engineering to regulate cell function and enhance the efficacy of cell therapy. This non-genetic engineering-based modification of the cell surface can functionalize cells within hours, significantly reducing manufacturing costs and processes without genetically modifying the cells, thereby making transient manipulation of cell functions feasible while avoiding potential safety risks. The highly specific biotin-avidin interaction exhibits remarkable resistance to harsh denaturing conditions, including heat, pH fluctuations, and organic solvents. Consequently, biotinylation holds immense promise in cell surface engineering. Cell surface-based biotinylation modification, leveraging the strong affinity between biotin molecules and avidin, enables the specific introduction of biotin on the cell surface, thereby functionalizing the cell through biotin-avidin binding. This technology typically involves the following steps: Introduction of biotin linker: Initially, molecules containing biotin linker groups must be introduced onto the cell surface. This can be accomplished through various methods, such as employing compounds containing biotin or utilizing biotin ligase to catalyze the covalent binding of biotin to cell surface molecules. Covalent binding of biotin linker with cell surface molecules: The biotin linker forms covalent bonds with molecules on the cell surface, thereby introducing biotin onto the cell membrane. This binding is typically highly specific, enabling the selective modification of specific cell surface structures. Interaction between biotin and avidin: Once the cell surface is labeled with biotin, the high -affinity interaction between biotin and avidin is utilized to functionalize the cell. Avidin is usually associated with fluorescent labels, polymers, or other molecular tags, which, upon specific binding with biotin, are introduced onto the cell surface, achieving functional modification of the cell. Functional application: Following the labeling of the cell surface with biotin and its binding to avidin, various functional modifications of the cell can be achieved. For instance, fluorescent labels can be utilized for cell imaging, drug carriers can be attached to the cell surface for drug delivery, or other functional molecules can be employed to regulate cell signaling, among other applications. Utilizing cell membrane coating technology to enhance the efficacy of drugs involves introducing additional cell membrane functions to increase their specificity. Although cell membrane-coated nanoparticles (CM-NPs) can achieve prolonged circulation, adding targeting ligands can enhance their localization to specific targets, such as tumors. This cell membrane-based ligand modification technology offers a simpler and more effective approach by combining natural cell membranes with different ligands for biological tasks. This strategy involves stabilizing functional ligand molecules on the extracellular domains of cell membrane proteins using cell-impermeable linkers. The crux of this method lies in coupling the ligand with cell membrane proteins, thereby achieving functional modification of the cell membrane. This cell membrane-based surface engineering technology offers drug delivery systems with enhanced specificity and targeting, particularly in fields like tumor therapy, with extensive application prospects.