Free and Open Source Software
Shoviv Microsoft 365 to Google Workspace Migration Tool
Shoviv Microsoft 365 to Google Workspace Migration Tool is a reliable software allowing users to move MS Office 365 to G Suite. This software comes with numerous user-centric features to provide an excellent working experience. It can process numerous emails from MS Office 365 to G Suite. The tool will not affect the folder structure and meta properties of the data. Most importantly, users do not need technical skills to migrate mailboxes from MS Office 365 to G Suite. This software allows creating or running multiple migration jobs at a time. Users can also choose the selective items to process with the Microsoft 365 to Google Workspace migration task. The users can easily preview the added mailboxes in this tool to ensure adding the correct one. It also allows users to schedule the migration job on a daily, weekly or monthly basis. Users can schedule their tasks at a specific time and date using its scheduler option. The tool's user interface is easy as a cakewalk; anyone can understand it without difficulty. Moreover, new users can move with this migration procedure using this tool. It also offers a free demo version, which users can download to check its features further.
InstaPro Apk latest version for Android 2023
Instagram Pro is a Modified version of the official Instagram application that allows users to enjoy many advanced features for free. It is well known that Instagram is a perfect social media platform for sharing photos and videos. With Instagram, users can share their videos and photos for their followers to like, comment, and share. Using this Instagram mod is a great deal of fun and it provides you with the freedom to enable smooth downloading of the stories, stories, videos, and much more on your device gallery for free.
TAC-Specific Plasmid
Global firm Creative Biolabs specializes in providing services for the development of cell therapies. T cell antigen connection (TAC) services that we offer include TAC design, building, validation, and scale-up production. Our objective is to advance preclinical trials for TAC-specific plasmid-based cell therapy for a variety of illness investigations. To fulfill our commitment today, we have assembled a group of gifted and driven scientists and professionals. We have created a library of TAC-specific plasmid products using a range of expression vectors that contains over 1,000 tumor targets and 25,000 unique TAC design features. Our goods are prepared for usage as virus particles, in pilot investigations, or for cloning.
Next-IO™ Anti-4-1BBL Therapeutic Fusion Protein Program
This program aims to develop anti-4-1BBL therapeutic fusion protein for immuno-oncology. The 4-1BBL agonistic antibodies, used alone or in combination with other anticancer drugs, have shown various therapeutic efficacies. However, presently, several ongoing clinical trials to evaluate the efficacy of agonistic 4-1BBL antibodies have reported significant hepatotoxicity and other complications in preclinical and clinical studies. In marked contrast, the latest data have dominated that 4-1BB ligand chimeric fusion protein shows robust T-effector responses with therapeutic efficacy in various preclinical tumor models, highlighting a clear rationale for 4-1BBL-FP-based cancer immunotherapy. For more: Next-IO™ Anti-4-1BBL Therapeutic Fusion Protein Program
Therapeutic Fc Characterization
Therapeutic antibody development and production are significant components of the biopharmaceutical sector and have had a significant positive impact on public health. To be clinically effective, therapeutic antibodies must perform two different types of functions: (i) target-specific binding via variable domains, and (ii) immune-mediated effector function via interaction of Fc (crystalllizable fragment) domains with cell receptors and complement proteins. By attaching to Fc-receptors (FcR) on immune cells or repairing complement, antibodies and antibody-based therapies have the potential to enhance immune function. The Fc region of the mAb must be described for IND and BLA submissions in accordance with the ICH Q6B and EMA mAb criteria. Therapeutic Fc characterisation was developed to promote the development of biobetter or biosimilar treatments after focusing on the development of antibody therapeutics for many years. In particular, we offer services for Fc engineering to control antibody function as well as cell-based functional tests for assessing antibody effector activities.
Ad fiber knob CD40 Miniantibody
A fusion protein made of two different scFv segments, Recombinant anti-Ad fiber knob CD40 miniantibody has anti-Ad fiber knob and anti-CD40 specificity. A flexible hinge region connects one scFv of an anti-Ad fiber knob antibody variable domain to another scFv of an anti-CD40 antibody variable domain. Compared to typical IgGs, this BsAb structure has a smaller size and greater penetration for clinical diagnosis and maybe therapy. Adenoviral vectors can be retargeted by this BsAb to tumor cells. It can be applied in cancer gene therapy to deliver a therapeutic gene to tumor cells with the goal of efficient and targeted cell death.
Bioinformatic solutions for cancer
Global researchers have amassed extensive experience in bioinformatics analysis to support whole genome sequencing (WGS), whole exome sequencing (WES), targeted sequencing, whole transcriptome sequencing (WTS), and immune repertoire sequencing thanks to years of research and development experience in the field of next-generation sequencing (NGS). We are able to provide premium custom bioinformatics analysis services to satisfy each and every one of our clients' particular needs. The development of NGS platforms places an increasing burden on statistical techniques and bioinformatic tools to handle and analyze the massive volumes of data. NGS technologies are becoming more and more crucial in the domains of oncology and immunology due to their cost-effectiveness, remarkable sequencing speed, high resolution, and accuracy in genomic analysis. For medical diagnosis and therapy, the combined power of NGS and bioinformatics solutions for cancer is essential.
Human Skin Model
Animal testing, which has been vehemently condemned by animal welfare organizations, is the principal method used to test the safety of cosmetics. In vitro cell studies are typically used to determine whether cosmetics are effective, however it can be challenging to accurately represent the actual world considering how intricate human skin tissue is. A global trend in recent decades has been the development of alternate methods for assessing genotoxicity and skin irritancy. Our created ex vivo human skin models are derived from actual human skin tissue to provide the most accurate test findings and a better representation of human biology. According to reports, the human skin model can be used to assess a number of skin conditions, including atopic dermatitis (AD), skin permeation, and abnormalities of the skin barrier. Our human skin models preserve the natural skin's structure, including cell population and dermal matrix, using the latest models and technologies. In order to evaluate the effectiveness of each cosmetic ingredient, our model can mimic several kinds of skin bacteria or skin microbiomes. Additionally, our model is able to simulate the actual state of cosmetics applied to the skin as well as translate subjectively perceived efficacy into particular data output, making it a more objective, scientific, and reliable evaluation model for cosmetic efficacy evaluation.
PreciAb™ Platform
In the last ten years, computer science and technology have advanced significantly, impacting every part of our lives. Since the late 1990s, computational biology has grown to play a significant role in the area of biology's new technologies. Scientists are now able to obtain structural information with greater detail thanks to advances in computer hardware development, such as the introduction of supercomputers and the programming language for computational biology. This information is crucial for understanding the various functions and mechanisms of biological molecules, but it also holds the key to the development of molecules with new or improved functions. B lymphocytes create the binding proteins known as antibodies to protect an organism from infections and foreign macromolecules. They are frequently utilized as medicinal medicines, diagnostic tools, and research tools. Antibody molecules are distinguished by their extreme diversity and recognition specificity. The development of phage display technology has made it possible to choose antibodies to any antigen with a suitable binding affinity, but antibody characteristics still need to be further improved for their application, particularly for therapy. When accessible, finely tuned antibody structures, including the structure of the antibody-antigen complex, are particularly helpful for designing and engineering antibodies. Key phases of antibody creation are detailed in our PreciAb™ Platform.
Single Cell Omics for CNAS
Recent years have seen the application of single cell omics to the study of cancer, including single-cell genomes, epigenomes, transcriptomes, proteomes, and multi-omics. In the study of cancer evolution, fascinating findings have been made on treatment resistance and the mysteries of the tumor microenvironment. Single-cell genome sequencing has recently been discovered to be extremely useful for the detection of somatic mutations, particularly during the evolution of tumors. DNA copy number abnormalities (CNAS) or an abnormally high number of chromosomes are common in cancer genomes. A discontinuous model of copy number evolution may also be important in other solid tumors, according to preliminary evidence from researchers utilizing single-cell gene sequencing in diseases such prostate, colon, liver, and lung cancer. The clinical diagnosis and management of cancer patients, as well as how evolutionarily we interpret the dynamics of tumor growth, are all significantly affected by this approach. For more: single cell Omics for CNAS