Software
Single Cell Omics for CNAS
Recent years have seen the application of single cell omics to the study of cancer, including single-cell genomes, epigenomes, transcriptomes, proteomes, and multi-omics. In the study of cancer evolution, fascinating findings have been made on treatment resistance and the mysteries of the tumor microenvironment. Single-cell genome sequencing has recently been discovered to be extremely useful for the detection of somatic mutations, particularly during the evolution of tumors. DNA copy number abnormalities (CNAS) or an abnormally high number of chromosomes are common in cancer genomes. A discontinuous model of copy number evolution may also be important in other solid tumors, according to preliminary evidence from researchers utilizing single-cell gene sequencing in diseases such prostate, colon, liver, and lung cancer. The clinical diagnosis and management of cancer patients, as well as how evolutionarily we interpret the dynamics of tumor growth, are all significantly affected by this approach. For more: single cell Omics for CNAS
Microfluidic Food Safety
The frequent occurrence of chemical (pesticide residues, heavy metals, and illegal additives) and biological (foodborne pathogens like Bacillus cereus, Listeria monocytogenes, Campylobacter jejuni, Sonne dysentery bacillus, E. coli, and Salmonella typhimurium) contaminations has made food safety a topic of international concern. As a result, food safety testing and analysis are crucial tools for preventing food contamination and resolving food safety issues. Historically, instrumental analysis has served as the foundation for most detection technologies. Even if it is accurate and trustworthy, instrumental analysis has some drawbacks, such as pricey equipment, a lengthy cycle, high material consumption, difficult operation, and low sensitivity. To meet the demands of on-site, real-time, quick, and portable food detection, it is imperative to design a novel analysis approach. Microfluidic Analysis in Food Safety The integration of sample pretreatment, separation, and detection into a chip with a few square centimeters has made microfluidic chip technology a hot topic in recent years. This allows sample pretreatment and follow-up analysis to be miniaturized, automated, integrated, and portable. It has been widely employed in the detection of pesticide residue, pathogenic bacteria, heavy metals, and food additives due to its benefits of low sample consumption, quick detection, simple operation, multi-functional integration, small size, and portability. For instance, a paper-based microfluidic device was created to detect leftover aminoglycoside antibiotics, Ag+, and Hg2+ simultaneously in food.
Qualify SARS-CoV-2 Vaccine
Infection can be prevented with vaccination, but it can also be treated through vaccination. Since the majority of potential vaccines fail in the preclinical and initial phase of research, vaccine development is a difficult, expensive, and dangerous process. Due to the intricacy of vaccine manufacture, it is crucial to completely comprehend the variables that will impact the formulation's safety, effectiveness, and stability. The selection of unfavorable conditions, or even a failure of safety, efficacy, or stability, could result from a lack of understanding of the elements that could have a negative impact on vaccine formulations and cause a project's delay or cancellation. As a result, when developing a vaccine, the evaluation of vaccine quality is crucial. It comprises assessing stabilizers, studying the interactions between antigen and adjuvant, evaluating product contact materials (such sterile filter membranes), and performing real-time and expedited stability monitoring. For more: SARS-CoV-2 vaccine qualification
Protein Modification Detection
Protein modification is the process of modifying proteins chemically either during or after translation. By adding functional groups to the protein, such as phosphate, acetate, amido, or methyl groups, protein modification detection expand the functional diversity of the proteome and have an impact on nearly every aspect of normal cell biology and disease. The regulation of gene expression, protein interactions, protein degradation, signaling, and regulatory mechanisms, as well as many other biological activities, depend on protein modification. The discovery of ribosomal proteomics has made it possible to modify ribosomal proteins, which represents a breakthrough in understanding the mystery of ribosomal protein function and offers a novel therapy approach for ribosome-related disorders. The properties of protein modification, including modification categories and modification sites, are crucial for cell biology, disease detection, and disease preventive studies as precision medicine advances.